Description
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Monomethylation of histone H3 at lysine 9 (H3K9Me1) is found at euchromatin regions of silenced genes and is correlated with gene repression.{48250} Recognition of H3K9Me1 by the H3K9 demethylases GLP and G9a is essential to embryonic stem cell differentiation and viability in mice.{49114} Cytoplasmic localization of H3K9Me1 is associated with reduced disease-specific mortality risk in patients with oral and/or oropharyngeal squamous cell carcinoma.{49115} Cayman’s Histone H3K9Me1 Monoclonal Antibody can be used for chromatin immunoprecipitation (ChIP), ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications.
Synonyms: Monomethylated Histone H3 Lysine 9
Immunogen: Peptide corresponding to H3K9Me1
Formulation: 100 µg of protein A-affinity purified monoclonal antibody
Isotype: IgG
Applications: ChIP, ELISA, ICC, multiplex-based assays, WB
Origin:
Stability: 365 days
Application|ELISA||Application|Immunocytochemistry||Application|Immunoprecipitation||Application|Multiplex||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Methylated
