Immunogen: 25-hydroxy Vitamin D3-BSA conjugate • Host: Rabbit • Species Reactivity: Species independent • Cross Reactivity: (+) 25-hydroxy Vitamin D3

25-hydroxy Vitamin D3 Rabbit Monoclonal Antibody – 100 µl

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Cayman
Storage:

25-hydroxy Vitamin D3 is an intermediate in the biosynthesis of 1α,25-dihydroxy vitamin D3 (calcitriol; Item No. 71820), a vitamin D receptor (VDR) agonist that has multiple functions, including stimulation of calcium absorption, insulin secretion, and cell proliferation and differentiation.{60080,60081,60082} It is produced from vitamin D3 (Item No. 11792) by 25-hydroxylase/CYP2R1 and bound to vitamin D binding protein (DBP) and albumin in the liver, then secreted into the bloodstream where it is the major circulating form of vitamin D.{60080} 25-hydroxy Vitamin D3 is transported to the kidney where it is hydroxylated by 1α-hydroxylase/CYP27B1 or 24-hydroxylase/CYP24A1 to produce 1α,25-dihydroxy vitamin D3 or 24,25-dihydroxy vitamin D3, respectively. Conversion of 25-hydroxy vitamin D3 to 1α,25-dihydroxy vitamin D3 is stimulated by parathyroid hormone (PTH) and inhibited by calcium, phosphorus, or FGF23. Serum 25-hydroxy vitamin D3 levels have been widely used as a marker of vitamin D status.{60081} Increased serum 25-hydroxy vitamin D3 levels are associated with increased bone density in patients with osteoarthritis, as well as reduced risk of colorectal, breast, and prostate cancer, whereas decreased serum 25-hydroxy vitamin D3 levels have been found in children with nutritional rickets, a condition caused by vitamin D deficiency and characterized by reduced bone density.{60081,60083,60084} Cayman’s 25-hydroxy Vitamin D3 Rabbit Monoclonal Antibody can be used for ELISA.  

 

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SKU: 32179 - 100 µl Category:

Description

Immunogen: 25-hydroxy Vitamin D3-BSA conjugate • Host: Rabbit • Species Reactivity: Species independent • Cross Reactivity: (+) 25-hydroxy Vitamin D3, 1α,25-hydroxy vitamin D3; (-) Vitamin D3, vitamin D2, 25-hydroxy vitamin D2, 1α,25-hydroxy vitamin D2 • Applications: ELISA ,,

Synonyms: 25(OH)D3|25-OH Vitamin D3|Calcidiol|Calcifediol

Immunogen: 25-hydroxy Vitamin D3-BSA conjugate

Formulation: 100 µl of protein A-affinity purified monoclonal antibody

Isotype: IgG

Applications: ELISA

Origin:

Stability: 365 days

Application|ELISA||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Cofactors & Vitamins||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Vitamin D Receptor||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)

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