Immunogen: Peptide from the internal region of human Hsp70 containing a citrulline at residue 155 • Host: Rabbit • Cross Reactivity: (+) Citrullinated Hsp70; (-) Hsp70

Citrullinated Hsp70 (R155) Polyclonal Antibody – 1 ea

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Cayman
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Heat shock protein 70s (Hsp70s) are abundant and stress-inducible 70 kDa molecular chaperone proteins encoded by a highly conserved, multigene family.{15480} They are monomeric proteins that can be divided into two functional domains: an N-terminal ATPase domain and a substrate binding domain that contains a highly conserved EEVD motif at its C-terminus. Hsp70s are found in the cytosol, nuclei, endoplasmic reticulum, mitochondria, and chloroplasts of eukaryotes, as well as in bacteria. They function as molecular chaperones that assist in a wide range of cellular processes, including refolding of aggregated or misfolded proteins, co- and post-translational folding and assembly of nascent peptides, membrane translocation of secretory and organellar proteins, controlling activity of regulatory nuclear receptors, kinases and transcription factors, as well as cooperativity with the Hsp90 chaperone system in eukaryotes.{36132} The Hsp70 chaperone cycle is ATP-dependent and initiated by transient interaction of the Hsp70 substrate binding domain with hydrophobic regions within a peptide or protein. It consists of an alteration between the low-affinity ATP-bound state with fast rates of substrate exchange and the high-affinity ADP bound state with slow rates of substrate exchange. Hsp70s are subject to a variety of post-translational modifications and their expression is upregulated under conditions of cellular stress and in a variety of disease states. Specifically, citrullinated Hsp70 peptides have been found in the synovial fluid of patients with rheumatoid arthritis.{31556} Cayman’s Citrullinated Hsp70 (R155) Polyclonal Antibody can be used for Western blot and ELISA applications.  

 

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Description

Immunogen: Peptide from the internal region of human Hsp70 containing a citrulline at residue 155 • Host: Rabbit • Cross Reactivity: (+) Citrullinated Hsp70; (-) Hsp70, other citrullinated Hsp proteins • Species Reactivity: (+) Human; other species not tested • Applications: ELISA and WB

Synonyms: Heat Shock Protein 70|HspA1A

Immunogen: Peptide from the internal region of Hsp70 containing a citrulline at residue 155

Formulation: 500 µl of peptide affinity-purified IgG

Isotype:

Applications: ELISA and WB

Origin:

Stability: 365 days

Application|ELISA||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis

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