Immunogen: Synthetic peptide from an internal region of human caspase-3 • Host: Rabbit • Species Reactivity: (+) Human and mouse; other species not tested • Cross Reactivity: (+) Caspase-2 (proform and active subunits) • Application(s): WB and IHC •

Caspase-3 (human) Polyclonal Antibody – 1 ea

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Cayman
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Apoptosis is associated with many diseases and is induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. Caspase-3 is a key effector caspase in the apoptosis cascade.{7216,6292} The enzyme is efficiently activated by caspase-8, caspase-9, and granzyme B resulting in 17 and 12 kDa active subunits formed from the 34 kDa proenzyme.{7216, 8444} The substrates of caspase-3 are numerous and include pro- and anti-apoptotic proteins, downstream components of the apoptotic machinery (for example, ICAD), as well as structural and homeostatic proteins.{7216,6292} DNA fragmentation and the morphological changes associated with this final stage of apoptosis appears to be dependent upon caspase-3.{6291} Caspase-3 is expressed in a variety of tissues and cells.{8444,8443}  

 

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SKU: 160745 - 1 ea Category:

Description

Immunogen: Synthetic peptide from an internal region of human caspase-3 • Host: Rabbit • Species Reactivity: (+) Human and mouse; other species not tested • Cross Reactivity: (+) Caspase-2 (proform and active subunits) • Application(s): WB and IHC •

Synonyms: Apopain|CASP3|Cysteine Protease CPP32|Protein Yama|SCA-1|SREBP Cleavage Activity 1

Immunogen: Synthetic peptide from an internal region of human caspase-3

Formulation: 500 µl Peptide affinity-purified polyclonal antibody

Isotype:

Applications: WB and IHC

Origin: Animal/Rabbit

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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