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15-hydroxy Prostaglandin Dehydrogenase Polyclonal Antibody – 1 ea

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Cayman
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NAD+-dependent 15-hydroxy PGDH catalyzes the oxidation of prostaglandins to 15-keto metabolites, which have greatly reduced biological activity.{340} Human NAD+-dependent 15-hydroxy PGDH is a 266 amino acid protein with a molecular weight of 29 kDa and is expressed in multiple tissues including lung, placenta, and kidney.{387} The enzyme belongs to a large family of short-chain alcohol dehydrogenases, which exhibit amino acid identity ranging from 15-30%.{8277,5201} An NADP+-dependent 15-hydroxy PGDH, which is also part of this enzyme family, exhibits only 20% amino acid identity to the NAD+-dependent enzyme.{8401} The peptide used as the antigen for preparation of the 15-hydroxy PGDH antibody is highly conserved across several species (see above), but has only minor homology to other proteins within the short-chain alcohol dehydrogenase family of enzymes (only the alanine and glycine at the N-terminus of the sequence appear to be conserved).{8277} Cayman’s 15-hydroxy PGDH Polyclonal Antibody can be used for Western blot applications. The antibody recognizes 15-hydroxy PGDH at 29 kDa from human, baboon, and mouse samples.  

 

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SKU: 160615 - 1 ea Category:

Description

Immunogen: Synthetic peptide from an internal region of human 15-hydroxy PGDH • Host: Rabbit • Species Reactivity: (+) Human, baboon, and mouse • Application: WB

Synonyms: 15-hydroxy PGDH

Immunogen: Synthetic peptide from an internal region of human 15-hydroxy PGDH

Formulation: Peptide Affinity-purified IgG

Isotype:

Applications: WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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