Immunogen: Portion of amino acids 100-150 of human SMAD3 • Host: Rabbit • Cross Reactivity: (+) Human

SMAD3 Polyclonal Antibody – 100 µg

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Cayman
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SMAD3, a member of the SMAD family of proteins, is involved in the TGF-β signaling cascade. A human homolog of Drosophila Mad protein, SMAD3 consists of an N-terminal DNA-binding MH1 domain, a linker region and a C-terminal MH2 domain. It is a receptor-regulated SMAD (R-SMAD) that functions downstream of TGF-β and activin receptors and mediates their signaling.{19270,19289} It is recruited by SARA (SMAD anchor for receptor activation) to the receptor kinase for phosphorylation. Upon phosphorylation, SMAD3 dissociates from SARA, forms a complex with SMAD4 and transmigrates into the nucleus where it complexes with other cofactors and acts as a transcription factor. It has an indispensable role in cell proliferation, differentiation, apoptosis and formation of ECM. Loss of SMAD3 results in childhood T cell leukemia.  

 

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SKU: 10832 - 100 µg Category:

Description

Immunogen: Portion of amino acids 100-150 of human SMAD3 • Host: Rabbit • Cross Reactivity: (+) Human, bovine, canine, mouse, porcine, primate, and rat • Application(s): IF, IHC, and WB • SMAD3 is a receptor-regulated SMAD (R-SMAD) that functions downstream of TGF-β and activin receptors and mediates their signaling. It is recruited by SARA (SMAD anchor for receptor activation) to the receptor kinase for phosphorylation. Upon phosphorylation it plays role in cell proliferation, differentiation, apoptosis and formation of ECM.

Synonyms:

Immunogen: Portion of amino acids 100-150 of human SMAD3

Formulation: 100 µg protein G-purified IgG

Isotype:

Applications: IF, IHC, and WB

Origin: Animal/Rabbit

Stability: 180 days

Application|Immunofluorescence||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cancer||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors

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