Raf-1 (Phospho-Ser642) Polyclonal Antibody – 1 ea

Brand:
Cayman
Storage:

The Ras pathway is a critical signal transduction cascade involved in regulating cellular proliferation, differentiation, survival, and oncogenic transformation. Members of the Raf serine/threonine kinase family are key intermediates in this cascade, functioning to relay signals from activated Ras to the downstream protein kinases MEK and ERK.{14542} Previous studies have shown that phosphorylation is required for Raf-1 activation.{14329,14539} Recent work has demonstrated that phosphorylation also regulates the down regulation of Raf with two sites participating: Ser301 and Ser642.{14540}  

 

Available on backorder

SKU: 10009505 - 1 ea Category:

Description

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser642 of rat raf-1 • Host: rabbit • Cross Reactivity: (+) rat raf-1; expected to react with bovine, canine, chicken, human, mouse, non-human primate, and Xenopus raf-1 • Application(s): WB • Members of the Raf serine/threonine kinase family function to relay signals from activated Ras to the downstream protein kinases MEK and ERK, which are critical for cellular proliferation, differentiation, survival, and oncogenic transformation. RAf-1 activity is regulated by phophorylation of Ser301 and Ser642.


Synonyms:

Immunogen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser642 of rat raf-1

Formulation: Affinity-purified IgG

Isotype:

Applications: WB

Origin: Animal/Rabbit

Stability: 365 days


Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Signaling