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Raf-1 (Phospho-Ser301) Polyclonal Antibody – 1 ea

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Cayman
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The Ras pathway is a critical signal transduction cascade involved in regulating cellular proliferation, differentiation, survival, and oncogenic transformation. Members of the Raf serine/threonine kinase family are key intermediates in this cascade, functioning to relay signals from activated Ras to the downstream protein kinases MEK and ERK.{14542} Previous studies have shown that phosphorylation is required for Raf-1 activation.{14329,14539} Recent work has demonstrated that phosphorylation also regulates the down regulation of Raf with two sites participating: Ser301 and Ser642.{14540}  

 

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SKU: 10009504 - 1 ea Category:

Description

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser301 of rat Raf-1 • Host: rabbit • Cross Reactivity: (+) rat Raf-1; expected to react with bovine, canine, chicken, human, mouse, non-human primate, and Xenopus Raf-1 • Application(s): WB • Studies have shown that phosphorylation is required for Raf-1 activation. Phosphorylation also down-regulates Raf with two sites participating: Ser301 and Ser642.

Synonyms:

Immunogen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser301 of rat raf-1

Formulation: Affinity-purified IgG

Isotype:

Applications: WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cell Biology|Cell Signaling

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