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5-Lipoxygenase (Phospho-Ser523) Polyclonal Antibody – 1 ea

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Cayman
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The enzyme 5-lipoxygenase (5-LO) plays a key role in regulating the production of leukotrienes (LTs).{12243} Overproduction of LTs contributes to several diseases, most notably chronic inflammatory diseases such as asthma, fibrosis,{956} and atherosclerosis. Recent work has demonstrated that the activity of 5-LO is regulated by protein kinase A (PKA) phosphorylation of serine-523 in 5-LO. Under normal conditions, this phosphorylation may be important in limiting inflammation. Abnormal signaling through cAMP and PKA, may therefore contribute to a variety of diseases, including those characterized by chronic inflammation. The phospho-specific antibody to Ser523 on 5-LO provides a valuable tool for studying the role of 5-LO regulation in diseases such as asthma, fibrosis, and atherosclerosis.  

 

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SKU: 10007820 - 1 ea Category:

Description

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser523 of human 5-LO • Host: rabbit • Cross Reactivity: (+) human, rat, and non-human primate 5-LO • Application: WB • 5-LO activity is regulated by PKA phosphorylation at serine-523. Under normal conditions, this phosphorylation may be important in limiting inflammation.

Synonyms: 5-LO (Phospho-Ser523) Polyclonal Antibody

Immunogen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser523 of human 5-lipoxygenase (5-LO)

Formulation: Affinity-purified rabbit polyclonal antibody

Isotype:

Applications: WB

Origin: Animal/Rabbit

Stability: 365 days

Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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