S1P1 Polyclonal Antibody – 1 ea

Brand:
Cayman
Storage:

Sphingosine-1-phosphate (S1P) exerts its activity by binding to five distinct G-protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8.{11895,12477} S1P1 primarily couples with pertussis toxin-sensitive Gi/o proteins to mediate S1P-induced cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis.{11895,12477,10628} Expression of S1P1 is abundant in embryological vasculature and is ubiquitously expressed in adult cells suggesting diverse physiological functions of this receptor.{12477} The human and mouse S1P1 receptors have 382 amino acids with an estimated molecular weight of 43 kDa. Glycosylation at the N-terminal extracellular domain may cause the protein to migrate at a higher position in SDS-PAGE.{12476} Cayman’s S1P1 Polyclonal Antibody detects the receptor at 47 kDa by WB analysis. The antibody can also be used for IF and IHC to study expression patterns of this protein.  

 

Available on backorder

SKU: 10005228 - 1 ea Category:

Description

Immunogen: Peptide from an internal cytoplasmic region of human S1P1 • Host: Rabbit • Species Reactivity: (+) Human, mouse, porcine, and rat S1P1 • Application(s): IF, IHC, and WB • S1P exerts its activity by binding to five distinct GPCRs, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P1 primarily mediates S1P-induced cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. Expression of S1P1 is abundant in embryological vasculature and is ubiquitously expressed in adult cells suggesting diverse physiological functions of this receptor.


Synonyms: EDG-1|S1PR1|Sphingosine-1-phosphate Receptor 1

Immunogen: Peptide from an internal cytoplasmic region of human S1P1

Formulation: 500 µl of peptide affinity-purified IgG

Isotype:

Applications: IF, IHC, and WB

Origin: Animal/Rabbit

Stability: 365 days


Application|Immunofluorescence||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area