Cayman’s 2’3’-cGAMP ELISA Kit is a competitive assay that can be used for quantification of 2’3’-cGAMP in cell lysates. This assay has a range from 100 ng/ml – 6.1 pg/ml with a midpoint of approximately 900 pg/ml (50% B/B0) and a sensitivity of approximately 85 pg/ml (80% B/B0). Powered by BIOLOG Life Science Institute

2’3′-cGAMP ELISA Kit – 96 solid wells

Brand:
Cayman
Storage:
4

Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that detects the presence of nucleic acids in the cytosol of mammalian cells as an indicator of bacterial or viral infection.{22400} cGAS catalyzes the synthesis of a second messenger, 2’3’-cGAMP, from cytosolic ATP and GTP in response to dsDNA binding. 2’3’-cGAMP then binds tightly to the adaptor protein STING (stimulator of interferon genes), resulting in the recruitment of TBK1 and subsequent IRF3 phosphorylation.{35370} IRF3 induces the transcription and translation type I interferon, a potent antiviral cytokine.{35369} Activation of cGAS and the production of 2’3’-cGAMP are important in host defense, but also may play role in autoimmune or inflammatory diseases. Modulation of cGAS activity, with subsequent inhibition of induction of 2’3’-cGAMP formation is an active target of pharmacological intervention.{35371} Powered by BIOLOG Life Science Institute.  

 

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Description

Cayman’s 2’3’-cGAMP ELISA Kit is a competitive assay that can be used for quantification of 2’3’-cGAMP in cell lysates. This assay has a range from 100 ng/ml – 6.1 pg/ml with a midpoint of approximately 900 pg/ml (50% B/B0) and a sensitivity of approximately 85 pg/ml (80% B/B0). Powered by BIOLOG Life Science Institute

Formulation:

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Synonyms:  2’3′-cGAMP EIA Kit|2’3′-Cyclic GMP-AMP|Guanosine-Adenosine 2′,3′-cyclic monophosphate

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Imunogen:

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Origin: Animal/Bovine|Animal/Rabbit

Application|ELISA||Product Type|Assay Kits|ELISA||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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