Description
Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.{57056} It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.{57056,53978} Trimethylation of histone H3 at lysine 4 (H3K4Me3) is found in euchromatic promoter regions and is associated with active transcription.{42709} It inhibits several H3K9 methyltransferases and has differential effects on the activities of the KDM7 demethylases PHF8 and KDM7A, activating and inhibiting H3K9Me3 demethylation, respectively. Mislocalization of H3K4Me3 is associated with disease progression and memory deficits in patients with Alzheimer’s disease.{42710} Cayman’s Histone H3K4Me3 Monoclonal Antibody can be used for chromatin immunoprecipitation (ChIP), ELISA, and multiplex-based assay applications.
Synonyms: Trimethylated Histone H3 Lysine 4
Immunogen: Peptide corresponding to H3K4Me3
Formulation: 100 µg of protein A-affinity purified monoclonal antibody
Isotype: IgG
Applications: ChIP, ELISA, multiplex-based assays
Origin:
Stability: 365 days
Application|ELISA||Application|Immunoprecipitation||Application|Multiplex||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Demethylation||Research Area|Epigenetics, Transcription, & Translation|Histones/Histone Peptides|Methylated||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease
