Description
FOX1, also known as ataxin-2-binding protein 1 (A2BP1) and RNA binding protein fox-1 homolog 1 (RBFOX1), is an RNA binding protein and alternative splicing regulator encoded by RBFOX1 in humans.{55207,55208,55209} RBFOX1 is expressed in the brain, skeletal muscle, and heart and undergoes splicing to generate tissue-specific isoforms.{55215} Neuron-specific FOX1 regulates alternative splicing of genes involved in neuronal development, proliferation, and maintenance.{55207} Mutations in RBFOX1, including exon deletion, frameshift, and copy number mutations, have been found in patients with rolandic epilepsy, autism, and schizophrenia.{55208,55220,55223} Cayman’s FOX1 Monoclonal Antibody can be used for immunofluorescence (IF) and Western blot (WB) applications. The antibody recognizes FOX1 isoforms at approximately 46 and 48 kDa from human, bovine, mouse, and rat samples.
Synonyms: A2BP1|Ataxin-2-binding Protein 1|RBFOX1|RNA Binding Protein Fox-1 Homolog 1
Immunogen: Recombinant protein from the N-terminus of human FOX1 expressed in E. coli
Formulation: 100 µl of protein G-purified monoclonal antibody
Isotype:
Applications: IF, WB
Origin:
Stability: 365 days
Application|Immunofluorescence||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis||Research Area|Neuroscience|Seizure Disorders
