Description
This antibody was purified by sequential peptide-affinity chromatography to select only for IgG specific for p53 (Ser392). Cellular p53, often called the ‘guardian of the genome’, is a transcription factor that is activated in response to cellular stress (DNA damage, hypoxia, heat shock, etc.) and acts to prevent further proliferation of the stressed cell by induction of cell cycle arrest or apoptotic mediators.{8237} Nearly 50% of human tumors have mutated or non-functional p53. p53 amino acid residues can be modified by phosphorylation and acetylation. In vivo phosphorylation of p53 residues alters signal transduction that warrant further investigation.{11275,11834}
Synonyms:
Immunogen: amino acids around phospho-Ser392
Formulation: 10 µg affinity-purified IgG in 100 µl HEPES, pH 7.5, containing 50% glycerol, 0.01% BSA, and 0.15 M sodium chloride
Isotype:
Applications: WB; other applications not tested
Origin: Animal/Rabbit
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53
