(−)-Viriditoxin – 500 µg

Brand:
Cayman
CAS:
1381782-08-6
Storage:
-20
UN-No:
Non-Hazardous - /

(−)-Viriditoxin is a mycotoxin originally isolated from A. viridinutans that has antibacterial and antiproliferative activity.{47137,47138,47139,47140} It is active against methicillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), tetracycline-sensitive and -resistant Staphylococcus, vancomycin-sensitive and -resistant Enterococcus, and penicillin-sensitive and -resistant S. pneumoniae (MICs = 2-32 μg/ml).{47138} (−)-Viriditoxin is also active against fish pathogens, including S. iniae and S. parauberis (MICs = 0.16-0.21 μg/ml).{47139} It inhibits polymerization and the GTPase activity of E. coli FtsZ, a tubulin-like GTPase involved in bacterial cell division (IC50s = 8.2 and 7 μg/ml, respectively).{47138} (−)-Viriditoxin inhibits proliferation of human DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5.36, 0.63, and 7.6 μM, respectively) .{47140} It is also toxic to mice (LD50 = 2.8 mg/kg, i.p.).{47141}  

 

Available on backorder

SKU: 26601 - 500 µg Category:

Description

A mycotoxin; active against MSSA and MRSA, tetracycline-sensitive and -resistant Staphylococcus, vancomycin-sensitive and -resistant Enterococcus, and penicillin-sensitive and -resistant S. pneumoniae (MICs = 2-32 μg/ml); active against fish pathogens, including S. iniae and S. parauberis (MICs = 0.16-0.21 μg/ml); inhibits polymerization and the GTPase activity of E. coli FtsZ (IC50s = 8.2 and 7 μg/ml, respectively); inhibits proliferation of human DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5.36, 0.63, and 7.6 μM, respectively)


Formal name: (3S,3’S,6R)-3,3′,4,4′-tetrahydro-9,9′,10,10′-tetrahydroxy-7,7′-dimethoxy-1,1′-dioxo-[6,6′-bi-1H-naphtho[2,3-c]pyran]-3,3′-diacetic acid, 3,3′-dimethyl ester

Synonyms: 

Molecular weight: 662.6

CAS: 1381782-08-6

Purity: ≥98%

Formulation: A solid


Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Small Molecule Inhibitors|GTPases||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Cancer||Research Area|Toxicology