A PDE4 inhibitor (IC50 = 0.22 µM for the guinea pig eosinophil enzyme); enhances isoprenaline-induced cAMP accumulation in isolated guinea pig eosinophils (EC50 = 0.19 µM); inhibits TNF and INF-γ production in L1402 CD4+ encephalitogenic rat T cells from 1-1

(−)-Rolipram – 5 mg

Brand:
Cayman
CAS:
85416-75-7
Storage:
-20
UN-No:
Non-Hazardous - /

(–)-Rolipram is a phosphodiesterase 4 (PDE4) inhibitor (IC50 = 0.22 µM for the guinea pig eosinophil enzyme) and an enantiomer of (±)-rolipram (Item No. 10011132).{52638} It enhances isoprenaline-induced cAMP accumulation in isolated guinea pig eosinophils (EC50 = 0.19 µM). (–)-Rolipram (1-1,000 µM) inhibits TNF and INF-γ production in L1402 CD4+ encephalitogenic rat T cells.{52639} It inhibits ovalbumin-induced contraction of tracheal rings isolated from ovalbumin-sensitized guinea pigs when used at a concentration of 1 µM.{52640} (–)-Rolipram inhibits ovalbumin-induced bronchoconstriction in guinea pigs (ED50 = 0.25 mg/kg).  

 

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SKU: 31111 - 5 mg Category:

Description

A PDE4 inhibitor (IC50 = 0.22 µM for the guinea pig eosinophil enzyme); enhances isoprenaline-induced cAMP accumulation in isolated guinea pig eosinophils (EC50 = 0.19 µM); inhibits TNF and INF-γ production in L1402 CD4+ encephalitogenic rat T cells from 1-1,000 µM; inhibits ovalbumin-induced contraction of tracheal rings isolated from ovalbumin-sensitized guinea pigs at 1 µM; inhibits ovalbumin-induced bronchoconstriction in guinea pigs (ED50 = 0.25 mg/kg)

Formal name: (4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone

Synonyms:  (R)-(–)-Rolipram|(R)-Rolipram

Molecular weight: 275.3

CAS: 85416-75-7

Purity: ≥98%

Formulation: A solid

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