An isoquinoline alkaloid and metabolite of L-THP with diverse biological activities; binds to human dopamine D1-5 receptors (Kis = 6.2

(−)-Isocorypalmine – 1 mg

Brand:
Cayman
CAS:
483-34-1
Storage:
-20
UN-No:
Non-Hazardous - /

(–)-Isocorypalmine is an isoquinoline alkaloid and a metabolite of L-tetrahydropalmitine (L-THP; Item No. 20535) that has been found in Corydalis and has diverse biological activities.{52469,52465,52466,52467,52468} It binds to human dopamine D1-5 receptors with Ki values of 6.2, 41.8, 37.3, 77.4, and 9.5 nM, respectively.{52465} (–)-Isocorypalmine inhibits Epstein-Barr virus-early antigen (EBV-EA) activation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in Raji cells (IC50 = 300 mol ratio/32 pmol TPA), which is predictive for anti-tumor activity.{52466} It is cytotoxic to A549, SKOV3, SK-MEL-2, and HCT15 cancer cells (IC50s = 67.32, 47.37, 47.66, and 67.32 μM, respectively).{52467} (–)-Isocorypalmine is active against clinical strains of C. albicans, C. glabratas, C. krusei, C. parapsilosis, and C. neoformans (MICs = 40-320 μg/ml).{52468}  

 

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Description

An isoquinoline alkaloid and metabolite of L-THP with diverse biological activities; binds to human dopamine D1-5 receptors (Kis = 6.2, 41.8, 37.3, 77.4, and 9.5 nM, respectively); inhibits TPA-induced EBV-EA activation in Raji cells (IC50 = 300 mol ratio/32 pmol TPA); cytotoxic to A549, SKOV3, SK-MEL-2, and HCT15 cancer cells (IC50s = 67.32, 47.37, 47.66, and 67.32 μM, respectively); active against clinical strains of C. albicans, C. glabratas, C. krusei, C. parapsilosis, and C. neoformans (MICs = 40-320 μg/ml)

Formal name: (13aS)-5,8,13,13a-tetrahydro-3,9,10-trimethoxy-6H-dibenzo[a,g]quinolizin-2-ol

Synonyms:  Isocorypalmine|L-Isocorypalmine

Molecular weight: 341.4

CAS: 483-34-1

Purity: ≥95%

Formulation: A solid

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