At 0.1-10 µM

δ-Tocotrienol – 1 mg

Brand:
Cayman
CAS:
25612-59-3
Storage:
-20
UN-No:
De Minimis - 1170 / 3

δ-Tocotrienol is a form of vitamin E that has been found in rice bran and has diverse biological activities.{3679,14290,14291,58093} It reduces cell death induced by hydrogen peroxide, paraquat, S-nitrocysteine, SIN-1 (Item No. 82220), or L-buthionine-(S,R)-sulfoximine (BSO; Item No. 14484) in rat striatal cultures when used at concentrations ranging from 0.1 to 10 µM.{14290} δ-Tocotrienol (10 µM) reduces 25-hydroxycholesterol-induced surface expression of VCAM-1 in human aortic endothelial cells (HAECs), as well as reduces 25-hydroxycholesterol-induced HAEC adhesion to U937 monocytes.{14291} It inhibits LPS-induced production of nitric oxide (NO), TNF-α, IL-6, IL-1β, and IFN-γ in RAW 264.7 cells. δ-Tocotrienol (60 mg/kg) increases the glomerular filtration rate and decreases renal malondialdehyde (MDA) levels in a rat model of nephrotoxicity induced by ochratoxin A (Item No. 11439).{58094}  

 

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SKU: 10008513 - 1 mg Category:

Description

At 0.1-10 µM, .delta.-tocotrienol significantly suppresses H2O2-induced cell death of rat striatal neurons and provides protection against S-nitrocysteine-induced cell death and SIN-1 cytotoxicity in a concentration dependant manner.{14290} At concentrations of 10 µM, .delta.-tocotrienol displays more inhibitory action on adhesiveness of HAECs to U937 monocytic cells, via inhibition of VCAM-1 expression, than α-tocopherol and other tocotrienols at the same concentration.{14291}

Formal name: 3,4-dihydro-2,8-dimethyl-2R-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol

Synonyms: 

Molecular weight: 396.6

CAS: 25612-59-3

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Natural Products|Vitamins||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Neuroprotection||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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