A biologically active form of vitamin E; reduces cumene hydroperoxide-induced lipid peroxidation in hepatocytes at 20 µM but induces lipid peroxidation in hepatic microsomes at 100 µM; decreases capillary formation of HMEC-1 blood endothelial cells at 40 µM; reduces estrogen-induced increases in the expression of estrogen-responsive genes and the levels of 8-oxo-dG and nitrotyrosine in MCF-7 cells at 10 µM/L; reduces tumor growth in an estrogen-supplemented MCF-7 mouse xenograft model at 0.2% in the diet

(+)-δ-Tocopherol – 50 mg

Brand:
Cayman
CAS:
119-13-1
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-δ-Tocopherol is a biologically active form of vitamin E, a lipid-soluble antioxidant that protects cellular membranes from oxidative damage.{8199,13784} It reduces cumene hydroperoxide-induced lipid peroxidation in hepatocytes when used at a concentration of 20 µM but induces lipid peroxidation in hepatic microsomes at 100 µM.{54400} (+)-δ-Tocopherol (40 µM) decreases capillary formation of HMEC-1 blood endothelial cells.{54401} It also decreases the expression of VCAM in, and the invasiveness of, HMEC-1 cells. (+)-δ-Tocopherol (10 µM) reduces estrogen-induced increases in the expression of the estrogen-responsive genes encoding TFF/pS2, cathepsin D, PGR, CITED1, and SERPINA1 and the levels of 8-hydroxy-2’-deoxyguanosine (8-oxo-dG) and nitrotyrosine in MCF-7 breast cancer cells.{54402} Dietary administration of (+)-δ-tocopherol (0.2%) reduces tumor growth in an estrogen-supplemented MCF-7 mouse xenograft model. [Matreya, LLC. Catalog No. 1790]  

 

Available on backorder

Add to quotes
SKU: 31589 - 50 mg Category:

Description

A biologically active form of vitamin E; reduces cumene hydroperoxide-induced lipid peroxidation in hepatocytes at 20 µM but induces lipid peroxidation in hepatic microsomes at 100 µM; decreases capillary formation of HMEC-1 blood endothelial cells at 40 µM; reduces estrogen-induced increases in the expression of estrogen-responsive genes and the levels of 8-oxo-dG and nitrotyrosine in MCF-7 cells at 10 µM/L; reduces tumor growth in an estrogen-supplemented MCF-7 mouse xenograft model at 0.2% in the diet

Formal name: (2R)-3,4-dihydro-2,8-dimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol

Synonyms:  D-δ-Tocopherol

Molecular weight: 402.7

CAS: 119-13-1

Purity: ≥98%

Formulation: A solution in hexane

Related products

  • A powerful effector in both the TetR and revTetR transcriptional regulator systems

    Anhydrotetracycline (hydrochloride) – 500 mg

    The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}  

     

    Brand:
    Cayman
    SKU:10009542 - 500 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 25 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 25 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 25 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 25 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A powerful effector in both the TetR and revTetR transcriptional regulator systems

    Anhydrotetracycline (hydrochloride) – 50 mg

    The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}  

     

    Brand:
    Cayman
    SKU:10009542 - 50 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page