A biologically active form of vitamin E; reduces cumene hydroperoxide-induced lipid peroxidation in hepatocytes at 20 µM but induces lipid peroxidation in hepatic microsomes at 100 µM; decreases capillary formation of HMEC-1 blood endothelial cells at 40 µM; reduces estrogen-induced increases in the expression of estrogen-responsive genes and the levels of 8-oxo-dG and nitrotyrosine in MCF-7 cells at 10 µM/L; reduces tumor growth in an estrogen-supplemented MCF-7 mouse xenograft model at 0.2% in the diet

(+)-δ-Tocopherol – 10 mg

Brand:
Cayman
CAS:
119-13-1
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-δ-Tocopherol is a biologically active form of vitamin E, a lipid-soluble antioxidant that protects cellular membranes from oxidative damage.{8199,13784} It reduces cumene hydroperoxide-induced lipid peroxidation in hepatocytes when used at a concentration of 20 µM but induces lipid peroxidation in hepatic microsomes at 100 µM.{54400} (+)-δ-Tocopherol (40 µM) decreases capillary formation of HMEC-1 blood endothelial cells.{54401} It also decreases the expression of VCAM in, and the invasiveness of, HMEC-1 cells. (+)-δ-Tocopherol (10 µM) reduces estrogen-induced increases in the expression of the estrogen-responsive genes encoding TFF/pS2, cathepsin D, PGR, CITED1, and SERPINA1 and the levels of 8-hydroxy-2’-deoxyguanosine (8-oxo-dG) and nitrotyrosine in MCF-7 breast cancer cells.{54402} Dietary administration of (+)-δ-tocopherol (0.2%) reduces tumor growth in an estrogen-supplemented MCF-7 mouse xenograft model. [Matreya, LLC. Catalog No. 1790]  

 

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Description

A biologically active form of vitamin E; reduces cumene hydroperoxide-induced lipid peroxidation in hepatocytes at 20 µM but induces lipid peroxidation in hepatic microsomes at 100 µM; decreases capillary formation of HMEC-1 blood endothelial cells at 40 µM; reduces estrogen-induced increases in the expression of estrogen-responsive genes and the levels of 8-oxo-dG and nitrotyrosine in MCF-7 cells at 10 µM/L; reduces tumor growth in an estrogen-supplemented MCF-7 mouse xenograft model at 0.2% in the diet

Formal name: (2R)-3,4-dihydro-2,8-dimethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol

Synonyms:  D-δ-Tocopherol

Molecular weight: 402.7

CAS: 119-13-1

Purity: ≥98%

Formulation: A solution in hexane

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