A xanthone with diverse biological activities: scavenges DPPH radicals in vitro (IC50 = 23.6 μM); is cytotoxic to HL-60

γ-Mangostin – 5 mg

Brand:
Cayman
CAS:
31271-07-5
Storage:
-20
UN-No:
Non-Hazardous - /

γ-Mangostin is a xanthone that has been found in G. mangostana and has diverse biological activities.{48253,48254,48255,48256} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in vitro with an IC50 value of 23.6 μM.{48253} γ-Mangostin is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, and SW480 cancer cells and BEAS-2B non-cancerous pulmonary epithelial cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 μM, respectively).{48254} It inhibits LPS-induced expression of IL-6, IL-10, and TNF-α in human macrophages in a concentration-dependent manner.{48255} Macrophage-conditioned media from macrophages pre-incubated with γ-mangostin (30 μM) prior to stimulation with LPS has a reduced ability to induce inflammation and insulin resistance in primary human adipocytes. γ-Mangostin (5 and 10 mg/kg) inhibits carbon tetrachloride-induced increases in serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) and decreases in hepatic superoxide dismutase 2 (SOD2) activity and glutathione (GSH) content in a mouse model of liver fibrosis.{48256}  

 

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Description

A xanthone with diverse biological activities: scavenges DPPH radicals in vitro (IC50 = 23.6 μM); is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 μM, respectively); inhibits LPS-induced expression of IL-6, IL-10, and TNF-α in human macrophages; macrophage-conditioned media from macrophages pre-incubated with γ-mangostin (30 μM) prior to stimulation with LPS has a reduced ability to induce inflammation and insulin resistance in primary human adipocytes; inhibits carbon tetrachloride-induced increases in serum levels of AST and ALT and decreases in hepatic SOD2 activity and GSH content in a mouse model of liver fibrosis

Formal name: 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one

Synonyms: 

Molecular weight: 396.4

CAS: 31271-07-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer|Cell Death||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Myeloperoxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase

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