A xanthone with diverse biological activities; inhibits growth of MRSA and MSSA (MICs = 6.25-12.5 and 6.25-25 μg/ml

β-Mangostin – 5 mg

Brand:
Cayman
CAS:
20931-37-7
Storage:
-20
UN-No:
Non-Hazardous - /

β-Mangostin is a xanthone originally isolated from G. mangostana with diverse biological activites.{39821,39822,39823,39824,39825,39826} It inhibits growth of methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA; MICs = 6.25-12.5 and 6.25-25 μg/ml, respectively), P. falciparum (IC50 = 3 μg/ml), and M. tuberculosis (MIC = 6.25 μg/ml).{39821,39822,39823} β-Mangostin inhibits fatty acid synthase (FASN) with an IC50 value of 24.83 μM.{39824} It induces cell cycle arrest at the G2/M phase and intrinsic and mitochondrial apoptosis in MCF-7 breast cancer cells.{39825} β-Mangostin also inhibits LPS-induced nitric oxide and prostaglandin E2 (PGE2; Item No. 14010) production in RAW264.7 cells and reduces neutrophil infiltration and TNF-α and IL-1β production in a mouse model of carrageenan-induced peritonitis.{39826}  

 

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SKU: 25071 - 5 mg Category:

Description

A xanthone with diverse biological activities; inhibits growth of MRSA and MSSA (MICs = 6.25-12.5 and 6.25-25 μg/ml, respectively), P. falciparum (IC50 = 3 μg/ml), and M. tuberculosis (MIC = 6.25 μg/ml); inhibits FASN (IC50 = 24.83 μM); induces cell cycle arrest at the G2/M phase and intrinsic and mitochondrial apoptosis in MCF-7 breast cancer cells; inhibits LPS-induced nitric oxide and PGE2 production in RAW264.7 cells; reduces neutrophil infiltration and TNF-α and IL-1β production in a mouse model of carrageenan-induced peritonitis,

Formal name: 1,6-dihydroxy-3,7-dimethoxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one

Synonyms: 

Molecular weight: 424.5

CAS: 20931-37-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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