Description
A human peptide with antimicrobial properties; induces migration of monocytes in vitro but does not affect migration of neutrophils and eosinophils (10 nM); stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes (30 μg/ml); stimulates calcium mobilization, migration, and proliferation of keratinocytes (30, 10, and 40 μg/ml, respectively); induces IL-31 production by human peripheral blood-derived mast cells in vitro (10 μg/ml); induces IL-31 production by rat mast cells in vivo (500 ng intradermal injection); inhibits growth of E. coli, P. aeruginosa, and S. aureus (LCs = 5, 12, and 15 μM, respectively), of S. carnosus (MIC = 4.5 μg/ml), and of C. albicans (MFC = 7.5 μM)
Formal name: L-α-glutamyl-L-leucyl-L-α-aspartyl-L-arginyl-L-isoleucyl-L-cysteinylglycyl-L-tyrosylglycyl-L-threonyl-L-alanyl-L-arginyl-L-cysteinyl-L-arginyl-L-lysyl-L-lysyl-L-cysteinyl-L-arginyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-tyrosyl-L-arginyl-L-isoleucylglycyl-L-arginyl-L-cysteinyl-L-prolyl-L-asparaginyl-L-threonyl-L-tyrosyl-L-alanyl-L-cysteinyl-L-cysteinyl-L-leucyl-L-arginyl-L-lysine, cyclic (6→33),(13→27),(17→34)-tris(disulfide), trifluoroacetate salt
Synonyms: hBD-4 (human)
Molecular weight: 4,366.10
CAS: 370570-43-7
Purity: ≥95%
Formulation: A lyophilized powder
Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Peptides||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases|Candidiasis
