A reversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase; blocks H2S synthesis in rat liver preparations with an IC50 value of 6.5 µM

β-cyano-L-Alanine – 100 mg

Brand:
Cayman
CAS:
6232-19-5
Storage:
-20
UN-No:
Non-Hazardous - /

Hydrogen sulfide (H2S) is a naturally-occurring gasotransmitter with vasodilator and inflammatory modulating activity.{15636,13678} H2S is synthesized naturally in a range of mammalian tissues principally by the activity of two enzymes, cystathionine γ lyase (CSE) and cystathionine β synthetase (CBS). β-cyano-L-Alanine (BCA) is a reversible inhibitor of the H2S-synthesizing enzyme CSE.{16454} BCA blocks H2S synthesis in rat liver preparations with an IC50 value of 6.5 µM and increases blood pressure in anaesthetized rats induced with hemorrhagic shock by inhibiting endogenous H2S synthesis.{16094} BCA at 50 mg/kg blocked both L-cysteine- and LPS-induced hyperalgesia in rats.{16455}  

 

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Description

A reversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase; blocks H2S synthesis in rat liver preparations with an IC50 value of 6.5 µM

Formal name: 3-cyano-L-alanine

Synonyms:  BCA

Molecular weight: 114.1

CAS: 6232-19-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Hydrogen Sulfide Synthesis||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypotension||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|H2S

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