A mycotoxin that inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase

β-Amanitin – 1 mg

Brand:
Cayman
CAS:
21150-22-1
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

β-Amanitin is a cyclic peptide found in several species of the Amanita genus, as well as other poisonous fungi.{29215} It inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis.{29205,20588} The biological activity of this toxin is similar to that of α-amanitin (Item No. 17898) but differs structurally by the presence of a carboxyl group, which is useful for coupling reactions.{29216}  

 

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Description

A mycotoxin that inhibits RNA polymerase II and III but not RNA polymerase I or bacterial RNA polymerase, thus preventing mammalian protein synthesis

Formal name: 1-L-aspartic acid-α-amanitin

Synonyms: 

Molecular weight: 920

CAS: 21150-22-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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