A reactive metabolite of tamoxifen that is formed by the action of CYP3A4 in human liver; can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety

α-hydroxy Tamoxifen – 5 mg

Brand:
Cayman
CAS:
97151-02-5
Storage:
-20
UN-No:
Non-Hazardous - /

Tamoxifen (Item No. 13258) is a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. Although it is an antagonist of ER action in breast tissue, it acts as an ER agonist in bone and blood vessels and a partial ER agonist in uterine tissues. α-hydroxy Tamoxifen is a reactive metabolite of tamoxifen that is formed by the action of cytochrome P450 3A4 in human liver.{28206,28212} It can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety, which in rats has been linked with hepatocarcinoma.{28206,28207,28208,28209,28211}  

 

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Description

A reactive metabolite of tamoxifen that is formed by the action of CYP3A4 in human liver; can be further converted into genotoxic DNA adducts though a mechanism involving reversible O-sulfonation of the hydroxyl moiety ,,

Formal name: (βE)-[[4-[2-(dimethylamino)ethoxy]phenyl]phenylmethylene]-α-methyl-benzeneethanol

Synonyms: 

Molecular weight: 387.5

CAS: 97151-02-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|DNA Damage and Repair||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Drug Metabolites

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