A sesquiterpene with diverse biological activities; lethal to A. subpictus

α-Humulene – 100 mg

Brand:
Cayman
CAS:
6753-98-6
Storage:
-20
UN-No:
Non-Hazardous - /

α-Humulene is a sesquiterpene that has been found in C. sativa, C. indica, and hemp with diverse biological activities.{41453,39866,39867,39868,39869} It is lethal to A. subpictus, A. albopictus, and C. tritaeniorhynchus mosquito larvae (LC50s = 6.19, 7.39, and 12.05 mg/ml, respectively).{39866} α-Humulene reduces growth of MCF-7 breast cancer cells by approximately 50% when used at a concentration of 32 mg/ml.{39867} It also reduces viability of Caco-2 cells in a concentration-dependent manner (IC50 = 24.4 mg/ml) but has no effect on viability of rat hepatocytes.{39868} In vivo, α-humulene (50 mg/kg) reduces histamine-induced paw edema in mice as well as carrageenan-induced TNF-α and IL-1β production and paw edema in mice and rats.{39869} It also reduces carrageenan-induced production of prostaglandin E2 (PGE2) and expression of inducible nitric oxide synthase (iNOS) and COX-2 in rats.  

 

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Description

A sesquiterpene with diverse biological activities; lethal to A. subpictus, A. albopictus, and C. tritaeniorhynchus mosquito larvae (LC50s = 6.19, 7.39, and 12.05 mg/ml, respectively); reduces growth of MCF-7 breast cancer cells by ~50% at 32 mg/ml; reduces viability of Caco-2 cells (IC50 = 24.4 mg/ml); reduces histamine-induced paw edema in mice as well as carrageenan-induced TNF-α and IL-1β production and paw edema in mice and rats at 50 mg/kg; reduces carrageenan-induced production of PGE2 and expression of iNOS and COX-2 in rats

Formal name: 2,6,6,9-tetramethyl-1E,4E,8E-cycloundecatriene

Synonyms:  (±)-α-Humulene|α-Caryophyllene

Molecular weight: 204.4

CAS: 6753-98-6

Purity: ≥97%

Formulation: A neat oil

Application||Product Type|Biochemicals|Natural Products|Phytocannabinoids||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Cancer||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins

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