A mycotoxin that selectively inhibits RNA polymerase II (1 µg/ml)

α-Amanitin – 1 mg

Brand:
Cayman
CAS:
23109-05-9
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

α-Amanitin is a cyclic peptide found in several species of the Amanita genus as well as other poisonous fungi.{29206} At 1, 10, and 50 µg/ml, respectively, α-amanitin inhibits RNA polymerase II, III, and IV, preventing translocation of the enzymes on DNA, which significantly slows the rate of transcription.{29205,20588} RNA polymerase I is insensitive to its effects. This toxin is used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies.{29205}  

 

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Description

A mycotoxin that selectively inhibits RNA polymerase II (1 µg/ml), preventing translocation of the enzymes on DNA; used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies

Formal name: α-Amanitin

Synonyms: 

Molecular weight: 919

CAS: 23109-05-9

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Product Type|Biochemicals|Toxins|Mycotoxins||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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