A non-enzymatic oxidation product of EPA; increased in the plasma and heart

(±)18-HEPE – 250 µg

Brand:
Cayman
CAS:
141110-17-0
Storage:
-20
UN-No:
Excepted Quantity - 1170 / 3

(±)18-HEPE is produced by non-enzymatic oxidation of eicosapentaenoic acid (EPA; Item Nos. 90110 | 90110.1 | 21908).{53027} 18-HEPE levels are increased in the plasma and heart, as well as in the supernatant of cultured peritoneal macrophages isolated from fat-1 transgenic mice that are capable of endogenously producing ω-3 fatty acids from ω-6 fatty acids.{53024,53025,53026} It reduces increases in cardiac fibrosis and the expression of Nppa, Col1a1, Tgfb1, Cx3cl1, and Adgre1 induced by transverse aortic constriction in a mouse model of cardiac hypertrophy when administered at doses of 1 and 5 µg.{53025}  

 

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SKU: 32840 - 250 µg Category:

Description

A non-enzymatic oxidation product of EPA; increased in the plasma and heart, as well as in the supernatant of cultured peritoneal macrophages isolated from fat-1 transgenic mice; reduces increases in cardiac fibrosis and the expression of Nppa, Col1a1, Tgfb1, Cx3cl1, and Adgre1 induced by transverse aortic constriction in a mouse model of cardiac hypertrophy at 1 and 5 µg

Formal name: (±)-18-hydroxy-5Z,8Z,11Z,14Z,16E-eicosapentaenoic acid

Synonyms: 

Molecular weight: 318.5

CAS: 141110-17-0

Purity: ≥97%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Hydroxy/Hydroperoxy/ Epoxy/Oxo Eicosanoids||Research Area|Cardiovascular System|Heart|Myocardial Hypertrophy||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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