The racemic version of a CYP450 metabolite of arachidonic acid that potently inhibits proximal tubule ATPase activity.

(±)17-HETE – 50 µg

Brand:
Cayman
CAS:
128914-47-6
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney. At a concentration of 2 µM the (S)-enantiomer of 17-HETE inhibits proximal tubule ATPase activity by as much as 70%, whereas the (R)-isomer is inactive.{3825}  

 

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SKU: 10010636 - 50 µg Category:

Description

The racemic version of a CYP450 metabolite of arachidonic acid that potently inhibits proximal tubule ATPase activity.

Formal name: (±)17-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid

Synonyms: 

Molecular weight: 320.5

CAS: 128914-47-6

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Hydroxy/Hydroperoxy/ Epoxy/Oxo Eicosanoids||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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