(±)17-HDHA is an autoxidation product of DHA in vitro.{7479

(±)17-HDHA – 50 µg

Brand:
Cayman
CAS:
90780-52-2
Storage:
-20
UN-No:
De Minimis - 1170 / 3

(±)17-HDHA is an autoxidation product of docosahexaenoic acid (DHA; Item No. 90310) in vitro.{7479,7491} It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.{7480,7490,7492} 17(S)-HDHA (Item No. 10009799) could be produced by enzymatic oxidation of DHA using soybean lipoxygenase (LO) and is the putative product of mammalian 15-LOs.{7492} 17(S)-HDHA was shown to be an inhibitor of U-46619 (Item No. 16450) -induced rabbit and rat aortic smooth muscle contraction with IC50 values of 4.9 and 7.2 µM, respectively.{7481} (±)17-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.  

 

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Description

(±)17-HDHA is an autoxidation product of DHA in vitro.{7479,7491} It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.{7480,7490,7492} 17(S)-HDHA can be produced by enzymatic oxidation of DHA using soybean LO and is the putative product of mammalian 15-LOs.{7492} 17(S)-HDHA is an inhibitor of U-46619-induced rabbit and rat aortic smooth muscle contraction with IC50 values of 4.9 and 7.2 µM, respectively.{7481} (±)17-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.

Formal name: (±)17-hydroxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid

Synonyms:  (±)17-HDoHE|17-hydroxy Docosahexaenoic Acid|17-hydroxy DHA

Molecular weight: 344.5

CAS: 90780-52-2

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Lipid Biochemistry|Reactive O2/N2 Pathways||Research Area|Neuroscience||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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