EDHF is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (NO) and COX-derived (prostacyclin) vasodilators.{6485

(±)14(15)-EpETE – 50 µg

Brand:
Cayman
CAS:
131339-24-7
Storage:
-20
UN-No:
De Minimis - 1170 / 3

EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.{6485,7204} Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE (Item No. 50651) which are prime candidates for the actual active mediator.{5826} However, the CYP450 metabolites of eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310) have been little studied relative to arachidonate epoxygenase metabolites. (±)14(15)-EpETE is the ω-3 homolog of 14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of (±)14(15)-EpETE has not yet been determined.  

 

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SKU: 10173 - 50 µg Category:

Description

EDHF is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (NO) and COX-derived (prostacyclin) vasodilators.{6485,7204} CYP450 metabolism of PUFAs, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator.{5826} However, the CYP450 metabolites of EPA (Item No. 90110) and DHA (Item No. 90310) have been little studied relative to arachidonate epoxygenase metabolites. (±)14(15)-EpETE is the ω-3 homolog of (±)14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of (±)14(15)-EpETE has not yet been determined.

Formal name: (±)14,15-epoxy-5Z,8Z,11Z,17Z-eicosatetraenoic acid

Synonyms:  (±)14,15 EEQ|(±)14,15-epoxy Eicosatetraenoic Acid

Molecular weight: 318.5

CAS: 131339-24-7

Purity: ≥90%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Hydroxy/Hydroperoxy/ Epoxy/Oxo Eicosanoids||Research Area|Lipid Biochemistry|Cytochrome P450 Pathways

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