A β-adrenergic receptor antagonist (Kds = 6.91

(±)-Propranolol (hydrochloride) – 25 g

Brand:
Cayman
CAS:
318-98-9
Storage:
4
UN-No:
Non-Hazardous - /

(±)-Propranolol is a β-adrenergic receptor (β-AR) antagonist (Kds = 6.91, 0.832, and 117.49 nM for human β1-, β2-, and β3-ARs, respectively).{25151} It reduces mean blood pressure, resting heart rate, and contractility and increases AV conduction time in dogs.{30090} (±)-Propranolol restores normal sinus rhythm in dogs with ouabain-induced arrhythmias (ED50 = 3.8 mg/kg).{39376} It also acts as a non-specific serotonin receptor antagonist, reducing tranylcypromine/L-tryptophan-induced hyperactivity in rats.{25891} Formulations containing (±)-propranolol have been used for the treatment of hypertension, angina pectoris, and cardiac ischemia.  

 

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SKU: 23349 - 25 g Category:

Description

A β-adrenergic receptor antagonist (Kds = 6.91, 0.832, and 117.49 nM for human β1-, β2-, and β3-ARs, respectively); reduces mean blood pressure, resting heart rate, and contractility and increases AV conduction time in dogs; restores normal sinus rhythm in dogs with ouabain-induced arrhythmias (ED50 = 3.8 mg/kg); acts as a non-specific serotonin receptor antagonist, reducing tranylcypromine/L-tryptophan-induced hyperactivity in rats,

Formal name: 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol, monohydrochloride

Synonyms:  ICI 45520|NSC 91523

Molecular weight: 295.8

CAS: 318-98-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Angina||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Heart|Myocardial Contractility

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