A RIPK1 inhibitor; 6 mg/kg/day prevents TNF-induced mortality in a murine model of SIRS; decreases irradiation-induced LDH release and cell death in murine embryonic Cyt c-/- cells; 1.6 mg/kg/day prevents angiotensin II-induced elastin degradation and aortic inflammation in a murine AAA model

(±)-Necrostatin-2 – 5 mg

Brand:
Cayman
CAS:
852391-15-2
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-Necrostatin-2 is a racemic mixture that inhibits receptor-interacting protein kinase 1 (RIPK1) autophosphorylation in vitro in a dose-dependent manner.{33477} Treatment with 6 mg/kg/day of (±)-necrostatin-2 prevents TNF-induced mortality in a murine model of systemic inflammatory response syndrome (SIRS). (±)-Necrostatin-2 decreases irradiation-induced lactate dehydrogenase (LDH) release and cell death in murine embryonic Cyt c-/- cells.{38080} It also prevents angiotensin II-induced elastin degradation and aortic inflammation in a murine abdominal aortic aneurism (AAA) model at a dose of 1.6 mg/kg/day.  

 

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Description

A RIPK1 inhibitor; 6 mg/kg/day prevents TNF-induced mortality in a murine model of SIRS; decreases irradiation-induced LDH release and cell death in murine embryonic Cyt c-/- cells; 1.6 mg/kg/day prevents angiotensin II-induced elastin degradation and aortic inflammation in a murine AAA model,

Formal name: 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione

Synonyms:  7-Cl-O-Nec-1|Nec-1s

Molecular weight: 277.7

CAS: 852391-15-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Cardiovascular Diseases

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