A monoterpene alcohol with diverse biological activities; induces cell cycle arrest at the G0/G1 and G2M phase in U937 and HeLa cells

(±)-Linalool – 10 mg

Brand:
Cayman
CAS:
78-70-6
Storage:
22
UN-No:
Non-Hazardous - /

(±)-Linalool is a monoterpene alcohol that has been found in C. sativa, C. indica, and hemp with diverse biological activities.{41453,21575,36770,36771,36772,42327} It induces cell cycle arrest at the G0/G1 and G2M phase in U937 and HeLa cells, respectively.{21575} (±)-Linalool is cytotoxic to U937 and HeLa cells (IC50s = 2.59 and 11.02 μM, respectively). It induces recruitment of a PGC-1α coactivator peptide to the PPARα ligand binding domain (EC50 = 5.45 μM in a TR-FRET assay).{36770} In vivo, (±)-linalool reduces plasma triglyceride concentration in mice fed a Western diet and transgenic mice expressing human ApoE2, but not PPARα-/- mice. It has molluscicidal and larvicidal effects in vitro (LC50s = 0.25 and 0.07 mg/L for O. hupensis and S. japonicium, respectively), and it reduces the amount of schitosomulum recovered from mouse skin after S. japonicium challenge infection.{36771} (±)-Linalool (10-40 mg/kg) reduces the number of macrophages and neutrophils and the production of TNF-α, IL-6, IL-1β, IL-8, and MCP-1 in bronchoalveolar lavage fluid (BALF) in a mouse model of cigarette smoke-induced acute lung inflammation.{36772} It also decreases immobility time in the forced swim test in mice, indicating antidepressant-like activity.{42327}  

 

Out of stock

Add to quotes
SKU: 21575 - Category:

Description

A monoterpene alcohol with diverse biological activities; induces cell cycle arrest at the G0/G1 and G2M phase in U937 and HeLa cells, respectively; cytotoxic to U937 and HeLa cells (IC50s = 2.59 and 11.02 μM, respectively); induces recruitment of a PGC-1α coactivator peptide to the PPARα ligand binding domain (EC50 = 5.45 μM in a TR-FRET assay); reduces plasma triglyceride concentration in mice fed a Western diet and transgenic mice expressing human ApoE2; has molluscicidal and larvicidal effects in vitro (LC50s = 0.25 and 0.07 mg/L for O. hupensis and S. japonicium, respectively); reduces the amount of schitosomulum recovered from mouse skin after S. japonicium challenge infection; reduces the number of macrophages and neutrophils and the production of TNF-α, IL-6, IL-1β, IL-8, and MCP-1 in BALF in a mouse model of cigarette smoke-induced acute lung inflammation from 10-40 mg/kg; decreases immobility time in the forced swim test in mice

Formal name: 3,7-dimethyl-1,6-octadien-3-ol

Synonyms:  dl-Linalool|NSC 3789

Molecular weight: 154.3

CAS: 78-70-6

Purity: ≥98%

Formulation: A liquid

Application||Product Type|Biochemicals|Antiparasitics|Anthelmintics||Product Type|Biochemicals|Natural Products|Phytocannabinoids||Product Type|Biochemicals|Natural Products|Terpenes||Research Area

Related products

  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 1 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 1 mg

    Available on backorder

    Add to quotes
    View product page
  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 50 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 50 mg

    Available on backorder

    Add to quotes
    View product page
  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 250 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 250 mg

    Available on backorder

    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 50 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 50 mg

    Available on backorder

    Add to quotes
    View product page