A class III antiarrhythmic agent; inhibits IKr in AT-1 myocytes (IC50 = 20 nM); enhances INa and increases the action potential duration in isolated guinea pig ventricular cells; decreases pinacidil-induced ventricular fibrillation in Langendorff isolated perfused rabbit hearts from 3-30 µM; increases the ERP of the left and right atrium in anesthetized pigs at 15 µg/kg

(±)-Ibutilide (hemifumarate) – 100 mg

Brand:
Cayman
CAS:
122647-32-9
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-Ibutilide is a class III antiarrhythmic agent.{55269} It inhibits the rapidly activating delayed-rectifier potassium current (IKr) in AT-1 myocytes with an IC50 value of 20 nM.{55273} (±)-Ibutilide also enhances the late inward sodium current (INa) and increases the action potential duration in isolated guinea pig ventricular cells.{55270} It decreases ventricular fibrillation induced by the ATP-dependent potassium channel activator pinacidil (Item No. 15416) in Langendorff isolated perfused rabbit hearts when used at concentrations ranging from 3 to 30 µM.{55271} (±)-Ibutilide (15 µg/kg, i.v.) increases the effective refractory period (ERP) of the left and right atrium in anesthetized pigs.{55272} It prevents rapid pacing-induced atrial flutter in dogs when administered orally at doses ranging from 0.25 to 5 mg/kg. Formulations containing ibutilide have been used in the treatment of atrial arrhythmias.  

 

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Description

A class III antiarrhythmic agent; inhibits IKr in AT-1 myocytes (IC50 = 20 nM); enhances INa and increases the action potential duration in isolated guinea pig ventricular cells; decreases pinacidil-induced ventricular fibrillation in Langendorff isolated perfused rabbit hearts from 3-30 µM; increases the ERP of the left and right atrium in anesthetized pigs at 15 µg/kg, i.v.; prevents rapid pacing-induced atrial flutter in dogs from 0.25-5 mg/kg

Formal name: N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide, 2E-butenedioate (2:1)

Synonyms:  U-70226E

Molecular weight: 442.6

CAS: 122647-32-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Heart|Arrhythmia

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