A naphthoquinone with diverse biological activities; exhibits fungicidal activity against ten agriculturally relevant plant fungi in vitro (MICs = 5-20 mg/L) and in infected wheat and barley plants (EC50s = 2-20 mg/L); reduces the growth of T. cruzi epimastigotes (IC50 = 4.01 μM); a substrate of NQO1 that increases production of ROS and induces cell death of A549 lung carcinoma cells (IC50 = 6.1 μM); increases intracellular NAD+ and prevents cisplatin-induced inflammatory cytokine production and small intestinal damage in mice when administered at a dose of 20 mg/kg per day for 4 days

(±)-Dunnione – 1 mg

Brand:
Cayman
CAS:
521-49-3
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-Dunnione is a naturally occurring naphthoquinone with diverse biological activities.{40460,40463,40461,40462} It exhibits fungicidal activity against ten agriculturally relevant plant fungi in vitro (MICs = 5-20 mg/L) and in infected wheat and barley plants (EC50s = 2-20 mg/L).{40460} (±)-Dunnione also reduces the growth of T. cruzi epimastigotes (IC50 = 4.01 μM).{40463} It is a substrate for NAD(P)H:quinone oxidoreductase 1 (NQO1) that increases production of reactive oxygen species (ROS) and induces cell death of A549 lung carcinoma cells (IC50 = 6.1 μM).{40461} (±)-Dunnione (20 mg/kg per day for 4 days) increases intracellular NAD+ (Item No. 16077) and prevents inflammatory cytokine production and small intestinal damage induced by cisplatin (Item No. 13119) in mice.{40462}  

 

Out of stock

Add to quotes
SKU: 21943 - Category:

Description

A naphthoquinone with diverse biological activities; exhibits fungicidal activity against ten agriculturally relevant plant fungi in vitro (MICs = 5-20 mg/L) and in infected wheat and barley plants (EC50s = 2-20 mg/L); reduces the growth of T. cruzi epimastigotes (IC50 = 4.01 μM); a substrate of NQO1 that increases production of ROS and induces cell death of A549 lung carcinoma cells (IC50 = 6.1 μM); increases intracellular NAD+ and prevents cisplatin-induced inflammatory cytokine production and small intestinal damage in mice when administered at a dose of 20 mg/kg per day for 4 days

Formal name: 2,3-dihydro-2,3,3-trimethyl-naphtho[1,2-b]furan-4,5-dione

Synonyms:  NSC 95403

Molecular weight: 242.3

CAS: 521-49-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Pesticides|Fungicides||Research Area|Cancer|Cell Death||Research Area|Cancer|Tumor Microenvironment||Research Area|Immunology & Inflammation||Research Area|Plant Biology

Related products

  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 100 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 100 mg

    Available on backorder

    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 50 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 50 µg

    Available on backorder

    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 500 µg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 500 µg

    Available on backorder

    Add to quotes
    View product page
  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 250 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 250 mg

    Available on backorder

    Add to quotes
    View product page