A potent and non-selective CB receptor agonist (Kis = 5 and 1.8 nM for human CB1 and CB2

(±)-CP 55,940 – 50 mg

Brand:
Cayman
CAS:
83003-12-7
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-CP 55,940 is a potent, non-selective cannabinoid (CB) receptor agonist (Kis = 5 and 1.8 nM for human CB1 and CB2, respectively).{7912} It stimulates [35S]GTPγS binding to rat cerebellar membranes (EC50s = 0.22-0.96 nM).{41807} In vivo, (±)-CP 55,940 induces analgesia in the tail clamp, hot plate, tail flick, flinch jump, and PBQ-induced writhing tests with 50% maximum possible effect (MPE50) values of 0.46, 1.11, 0.55, 0.63, and 0.29 mg/kg, respectively.{6752} (±)-CP 55,940 also decreases the discrimination index (DI) of female, but not male, rats in the object location task as well as the DI of male, but not female, rats in the novel object recognition task.{41808}  

 

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Description

A potent and non-selective CB receptor agonist (Kis = 5 and 1.8 nM for human CB1 and CB2, respectively); stimulates [35S]GTPγS binding to rat cerebellar membranes (EC50s = 0.22-0.96 nM); induces analgesia in the tail clamp, hot plate, tail flick, flinch jump, and PBQ-induced writhing tests (MPE50s = 0.46, 1.11, 0.55, 0.63, and 0.29 mg/kg, respectively); decreases DI of female, but not male, rats in the object location task as well as the DI of male, but not female, rats in the novel object recognition task

Formal name: rel-5-(1,1-dimethylheptyl)-2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-phenol

Synonyms: 

Molecular weight: 376.6

CAS: 83003-12-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Cannabinoid Research|CB1 & CB2 Receptors||Research Area|Neuroscience|Pain Research

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