A GABAB receptor agonist (IC50 = 180 nM); induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM); increases muscle rigidity in spastic mice at 10 mg/kg; inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats; reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice

(±)-Baclofen – 5 g

Brand:
Cayman
CAS:
1134-47-0
Storage:
-20
UN-No:
Excepted Quantity - 2811 / 6.1

(±)-Baclofen is a GABAB receptor agonist (IC50 = 180 nM).{46227} It induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM). (±)-Baclofen (10 mg/kg) increases muscle rigidity in spastic mice.{30075} It inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats.{30078} (±)-Baclofen also reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice.{30076,30077} Formulations containing baclofen have been used to treat muscle spasms caused by multiple sclerosis and spinal cord injury.  

 

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Description

A GABAB receptor agonist (IC50 = 180 nM); induces norepinephrine release from isolated rat atria (IC50 = 4.5 μM); increases muscle rigidity in spastic mice at 10 mg/kg; inhibits the norepinephrine-induced group II flexor reflex in anesthetized rats; reduces cocaine-induced hyperlocomotion in rats and binge-like ethanol intake in mice

Formal name: β-(aminomethyl)-4-chloro-benzenepropanoic acid

Synonyms: 

Molecular weight: 213.7

CAS: 1134-47-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research

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