A dopamine receptor agonist (EC50s = 3.5 and 0.65 μM in rat striatal and nucleus accumbens homogenates

(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (hydrobromide) – 25 mg

Brand:
Cayman
CAS:
13575-86-5
Storage:
-20
UN-No:
Non-Hazardous - /

(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN) is a dopamine receptor agonist (EC50s = 3.5 and 0.65 μM in rat striatal and nucleus accumbens homogenates, respectively).{41296} 6,7-ADTN stimulates production of cAMP in rat striatal homogenates, a process that is reduced by 70% in the presence of the dopamine antagonist fluphenazine (Item No. 23555) at a concentration of 1 μM. In vivo, 6,7-ADTN induces hyperlocomotion in rats when injected bilaterally at a dose of 100 nmol per side into the nucleus accumbens. It increases cAMP production and glycoprotein secretion in the albumen gland of H. duryi (snail).{41297} It also reduces sucrose feeding in R. maderae (cockroach) nymphs.{41298}  

 

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SKU: 23866 - 25 mg Category:

Description

A dopamine receptor agonist (EC50s = 3.5 and 0.65 μM in rat striatal and nucleus accumbens homogenates, respectively); stimulates production of cAMP in rat striatal homogenates, a process that is reduced by 70% in the presence of dopamine antagonist fluphenazine at a concentration of 1 μM; induces hyperlocomotion in rats when injected bilaterally at a dose of 100 nmol per side into the nucleus accumbens; increases cAMP production and glycoprotein secretion in the albumen gland of H. duryi (snail); reduces sucrose feeding in R. maderae (cockroach) nymphs

Formal name: 6-amino-5,6,7,8-tetrahydro-2,3-naphthalenediol, monohydrobromide

Synonyms:  (±)-ADTN|6,7-ADTN|6,7-diOHATN|NSC 287353

Molecular weight: 260.1

CAS: 13575-86-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience

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