A precursor of cholesterol; an agonist of RORγ (EC50 = 1 µM in the presence of ursolic acid); accumulates in cells following administration of AEBS ligands; halts the cell cycle at the G0/G1 phase and increases the levels of free sterols

Zymostenol – 50 mg

Brand:
Cayman
CAS:
566-97-2
Storage:
-20
UN-No:
Non-Hazardous - /

Zymostenol is a late-stage precursor in the biosynthesis of cholesterol.{48201} It is an agonist of retinoic acid receptor-related orphan receptor γ (RORγ) with an EC50 value of 1 µM in a RORγ coactivator recruitment assay in the presence of ursolic acid (Item No. 10072). It increases the number of myelin basic protein-positive oligodendrocytes generated from oligodendrocyte precursor cells in vitro.{48202} Zymostenol accumulates in cells following administration of microsomal antiestrogen-binding site (AEBS) ligands, such as tamoxifen (Item No. 13258), which are associated with cell differentiation and a protective type of autophagy.{48203,48204} When used alone at a concentration of 20 µM, zymostenol halts the cell cycle at the G0/G1 phase and increases the levels of free sterols, esterified sterols, and triacylglycerols in MCF-7 cells.{48203}  

 

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Description

A precursor of cholesterol; an agonist of RORγ (EC50 = 1 µM in the presence of ursolic acid); accumulates in cells following administration of AEBS ligands; halts the cell cycle at the G0/G1 phase and increases the levels of free sterols, esterified sterols, and triacylglycerols in MCF-7 cells at 20 µM

Formal name: (5α)-cholest-8-en-3β-ol

Synonyms:  Δ8-Cholesterol

Molecular weight: 386.7

CAS: 566-97-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer|Cell Cycle|G1||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience

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