A selective inhibitor of class I PI3K isoforms (IC50s = 17

ZSTK474 – 5 mg

Brand:
Cayman
CAS:
475110-96-4
Storage:
-20
UN-No:
Non-Hazardous - /

ZSTK474 is a triazine derivative that acts as an inhibitor of class I phosphatidylinositol 3-kinase (PI3K) isoforms (IC50s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively).{29699} It is selective for PI3K, as it has negligible activity against 139 other kinases when tested at 30 µM.{29699} ZSTK474 is orally bioavailable and shows strong antitumor activity against human cancer xenografts in mice.{29699} The efficacy of ZSTK474 against certain cancer cells and tumors can be enhanced by combination therapy.{29698,29697}  

 

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Description

A selective inhibitor of class I PI3K isoforms (IC50s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively); orally bioavailable, showing strong antitumor activity against human cancer xenografts in mice

Formal name: 2-(difluoromethyl)-1-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)-1H-benzimidazole

Synonyms: 

Molecular weight: 417.4

CAS: 475110-96-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling

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