A potent and selective VEGFR2 inhibitor; selective for VEGFR2 over VEGFR1

ZM 323881 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
193000-39-4
Storage:
-20
UN-No:
Non-Hazardous - /

ZM 323881 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2; IC50 = 50 = 8 nM) but not basal proliferation or that stimulated by EGF or bFGF (IC50s = >5,000, 1,900, and 1,600 nM, respectively).  

 

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SKU: 21347 - Category:

Description

A potent and selective VEGFR2 inhibitor; selective for VEGFR2 over VEGFR1, PDGFRβ, FGFR1, EGFR, and ErbB2 at concentrations greater than 50 µM; inhibits VEGF-A-stimulated cell proliferation of HUVECs (IC50 = 8 nM)

Formal name: 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-phenol, monohydrochloride

Synonyms: 

Molecular weight: 411.9

CAS: 193000-39-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Vasculature|Angiogenesis

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