Inhibits KDR and Flt VEGF receptors with IC50 values of 100 nM and 2 μM

ZM 306416 – 5 mg

Brand:
Cayman
CAS:
690206-97-4
Storage:
-20
UN-No:
Non-Hazardous - /

ZM 306416 is an inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinase that antagonizes the activity of KDR and Flt VEGF receptors with IC50 values of 100 nM and 2 μM, respectively.{27741} It has also been reported to inhibit EGFR kinase with an IC50 value of < 10 nM, reducing proliferation of EGFR-dependent cancer cells.{27752}  

 

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Description

Inhibits KDR and Flt VEGF receptors with IC50 values of 100 nM and 2 μM, respectively; also inhibits EGFR kinase (IC50 < 10 nM), reducing proliferation of EGFR-dependent cancer cells

Formal name: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine

Synonyms:  CB-676475

Molecular weight: 333.7

CAS: 690206-97-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|EGFR/ErbB/HER Family||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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