A dual agonist of FFAR1/GPR40 (EC50 = 68 nM in a FLIPR assay) and PPARδ (102 nM in a reporter assay); selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 µM for both); reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in the ob/ob mouse model of metabolic disease at 40 mg/kg; reduces hepatic steatosis and plasma ALT and AST levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet at 40 mg/kg

ZLY032 – 5 mg

Brand:
Cayman
CAS:
2314465-67-1
Storage:
-20
UN-No:
Non-Hazardous - /

ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50 = 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50 = 102 nM in a reporter assay).{57228} It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 µM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in the ob/ob mouse model of metabolic disease.{57229} It reduces hepatic steatosis and plasma alanine transaminase (ALT) and aspartate aminotransferase (AST) levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet at the same dose.  

 

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Description

A dual agonist of FFAR1/GPR40 (EC50 = 68 nM in a FLIPR assay) and PPARδ (102 nM in a reporter assay); selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 µM for both); reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in the ob/ob mouse model of metabolic disease at 40 mg/kg; reduces hepatic steatosis and plasma ALT and AST levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet at 40 mg/kg

Formal name: (3S)-2,3-dihydro-6-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]-3-benzofuranacetic acid

Synonyms: 

Molecular weight: 449.4

CAS: 2314465-67-1

Purity: ≥98%

Formulation: A solid

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