A small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells

ZLN005 – 25 mg

Brand:
Cayman
CAS:
49671-76-3
Storage:
-20
UN-No:
Non-Hazardous - /

Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis.{13340} ZLN005 is a small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM.{22056} Chronic administration of 15 mg/kg/day ZLN005 to diabetic db/db mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity.{22056}  

 

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Description

A small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM; 15 mg/kg/day administered to diabetic db/db mice improved glucose tolerance, pyruvate tolerance, and insulin sensitivity

Formal name: 2-[4-(1,1-dimethylethyl)phenyl]-1H-benzimidazole

Synonyms: 

Molecular weight: 250.3

CAS: 49671-76-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Activators|Transcription Factors & Coactivators||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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