A prodrug formulation of a potent DP-receptor agonist that is designed to enhance corneal absorption; lowers monkey and rabbit IOP 46% and 20%

ZK118182 isopropyl ester – 500 µg

Brand:
Cayman
CAS:
154927-31-8
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2α and PGD2, have been shown to reduce IOP. ZK118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM).{18721} ZK118182 isopropyl ester is a prodrug formulation of ZK118182 designed to enhance corneal absorption. At 0.03 μg, ZK118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.{9839}  

 

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Description

A prodrug formulation of a potent DP-receptor agonist that is designed to enhance corneal absorption; lowers monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing at 0.03 μg demonstrating a much more potent effect compared to the free acid

Formal name: [[4-[5R-chloro-2Z-[3R-cyclohexyl-3S-hydroxy-1R-propenyl]-3S-hydroxycyclopentyl]-2R-butenyl]oxy]-acetic acid, isopropyl ester

Synonyms: 

Molecular weight: 429

CAS: 154927-31-8

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Ophthalmology

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