An antagonist of the vitamin D receptor; inhibits VDR-mediated target gene activation at 300 and 1

ZK 159222 – 500 µg

Brand:
Cayman
CAS:
156965-15-0
Storage:
-80
UN-No:
Non-Hazardous - /

ZK 159222 is an antagonist of the vitamin D receptor (VDR).{52664,52665} It stabilizes the VDR in an antagonistic conformation that prevents interaction with coactivator proteins.{52666} ZK 159222 inhibits VDR-mediated target gene activation when used at concentrations of 300 and 1,000 nM in reporter assays. Preincubation of preadipocytes with ZK 159222 (0.01 and 1 µM) decreases the secretion of IL-1β, IL-6, IL-8, CCL2, and RANTES induced by macrophage-conditioned medium (MacCM).{52667} It also decreases the secretion of these cytokines in preadipocytes prestimulated with MacCM and decreases MacCM-induced phosphorylation of p44/42 and p38 MAPK in preadipocytes.  

 

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SKU: 9001925 - 500 µg Category:

Description

An antagonist of the vitamin D receptor; inhibits VDR-mediated target gene activation at 300 and 1,000 nM in reporter assays; decreases MacCM-induced secretion of IL-1β, IL-6, IL-8, CCL2, and RANTES in preadipocytes following preincubation at 0.01 and 1 µM

Formal name: 1-[(1R,2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-hydroxy-2-penten-1-yl]-cyclopropanecarboxylic acid, butyl ester

Synonyms: 

Molecular weight: 512.7

CAS: 156965-15-0

Purity: ≥95%

Formulation: A solid

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