A phenolic ketone; scavenges DPPH radicals in a cell-free assay (EC50 = 41.6 μmol); prevents myocardial expression of TNF-α

Zingerone – 50 g

Brand:
Cayman
CAS:
122-48-5
Storage:
-20
UN-No:
Non-Hazardous - /

Zingerone is a phenolic ketone originally isolated from ginger that has antioxidant, anti-inflammatory, anticarcinogenic, and antidiarrheal activities.{42113,42114} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay with an EC50 value of 41.6 μmol.{42115} Zingerone (6 mg/kg per day) prevents myocardial expression of TNF-α, IL-1β, and IL-6 in rats following myocardial infarction induced by isoproterenol (Item No. 15592).{42116} It decreases 1,2-dimethylhydrazine-induced tumor incidence by 67% and aberrant crypt foci formation by 68.85% in rats when administered at a dose of 20 mg/kg per day.{42117} Zingerone (10 mM) decreases E. coli heat-labile enterotoxin-induced fluid accumulation in the ileal loop of mice.{42118}  

 

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SKU: 24909 - 50 g Category:

Description

A phenolic ketone; scavenges DPPH radicals in a cell-free assay (EC50 = 41.6 μmol); prevents myocardial expression of TNF-α, IL-1β, and IL-6 in rats following isoproterenol-induced myocardial infarction at 6 mg/kg per day; decreases 1,2-dimethylhydrazine-induced tumor incidence by 67% and aberrant crypt foci formation by 68.85% in rats at 20 mg/kg per day; decreases E. coli heat-labile enterotoxin-induced fluid accumulation in the ileal loop of mice at 10 mM,,

Formal name: 4-(4-hydroxy-3-methoxyphenyl)-2-butanone

Synonyms:  NSC 15335|Vanillylacetone

Molecular weight: 194.2

CAS: 122-48-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Non-enzymatic

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