A selective BChE inhibitor (IC50 = 21 nM for hBChE); inhibits Aβ1-42 self-induced aggregation by 61.7% and protects human neuronal SH-SY5Y cells from Aβ1-42 peptide toxicity

ZINC12613047 – 5 mg

Brand:
Cayman
CAS:
1069521-64-7
Storage:
-20
UN-No:
Non-Hazardous - /

ZINC12613047 is a selective butyrylcholinesterase (BChE) inhibitor with an IC50 value of 21 nM for human BChE versus an IC50 value of 102.1 µM for mouse AChE.{27413} At 10 µM, it has been shown to inhibit Aβ1-42 self-induced aggregation by 61.7% and to protect human neuronal SH-SY5Y cells from Aβ1-42 peptide toxicity.{27413}  

 

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Description

A selective BChE inhibitor (IC50 = 21 nM for hBChE); inhibits Aβ1-42 self-induced aggregation by 61.7% and protects human neuronal SH-SY5Y cells from Aβ1-42 peptide toxicity

Formal name: N-[[1-(2,3-dihydro-1H-inden-2-yl)-3-piperidinyl]methyl]-N-(2-methoxyethyl)-2-naphthalenecarboxamide

Synonyms: 

Molecular weight: 442.6

CAS: 1069521-64-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Acetylcholine Turnover||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neuroprotection

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